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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described by their focus on practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for 프라그마틱 정품 사이트 프라그마틱 슬롯 - Read the Full Guide - a pragmatic trial to be reliable and to reduce bias in the results, is also necessary. However excessive heterogeneity could result in problems with the design of the trial.

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The purpose of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be a great method of determining the cause-effect relationship between an intervention and its results. However, they shouldn't be used as a substitute for explanation trials.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, as well as monitoring.

There is a positive increase in the number pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.